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Common Name: Dinotefuran (ISO name) Chemical Name: (RS)-1-methyl-2-nitro-3-(tetrahydro-3-furylmethyl) guanidine Melting Point: 107.5° C Water Solubility: 39.83 g/ Skin Irritation (Technical) Slightly Irritating Long Term Health Effects (Technical) Dinotefuran is not a mutagen, neurotoxin or reproductive toxin. Control of insect pests such as aphids, whiteflies, thrips, leafhoppers, leafminers, sawflies, mole cricket, white grubs lacebugs,
Ecological Effect Dinotefuran is highly toxic to honeybees and silkworms. Dinotefuran is a quick-kill insecticide discovered by researchers at Mitsui Chemicals. A third generation neonicotinoid, dinotefuran was synthesized with acetycholine as the lead compound, making it different from other flea control products currently in use which are In addition, dinotefuran does not bind to the same insect receptor sites in the nerve synapse as imidacloprid and other neonicotinoids. The binding is permanent causing continuous nerve stimulation and death of the insect. Ingestion is not necessary. Dinotefuran kills by contact. NOMENCLATURE Common name dinotefuran (BSI; Pa ISO) IUPAC name (RS)-1-methyl-2-nitro-3-(tetrahydro-3-furylmethyl)guanidine Chemical Abstracts name N-methyl-N'-nitro-N''-[(tetrahydro-3-furanyl)methyl]guanidine CAS RN [165252-70-0] Development codes MTI-446 (Mitsui) PHYSICAL CHEMISTRY Mol. Wt. 202.2 M. F. C7H14N4O3 M. P. 94.5-101.5 ° C KOW logP = -0.644 (pH 7) S. G. /density 1.33 Solubility In purified water 54.3? . 3 g/l (20 ° C). PKa No dissociation in range pH 1.4 to 12.3 APPLICATIONS Biochemistry Agonist of the nicotinic acetylcholine receptor, affecting the synapses in the insect central nervous system. Mode of action Active by ingestion and by contact; Also exhibits root-systemic activity. Uses Controls a range of hemipterous and other pests, at 100-200 g/ha. MAMMALIAN TOXICOLOGY Oral Acute oral LD50 for male rats 2804, female rats 2000, male mice 2450, female mice 2275 mg/kg. Skin and eye Acute percutaneous LD50 for male and female rats >2000 mg/kg. Not a skin sensitiser (guinea pigs). ECOTOXICOLOGY Birds Acute oral LD50 for mallard ducks 1000, Japanese quail >2000 mg/kg. Fish LC50 (96 h) for carp >1000 ppm; (48 h) for rainbow trout >40 ppm. Daphnia (48 h) 1000 ppm Other aquatic spp. LC50 (48 h) for crayfish 5-10 ppm.
CAS Registry Number
334.531°C at 760 mmHg
0mmHg at 25°C
Biochemistry Agonist of the nicotinic acetylcholine receptor, affecting the synapses in the insect central nervous system. Mode of action Active by ingestion and by contact; also exhibits root-systemic activity. Uses Controls a range of hemipterous and other pests, at 100-200 g/ha.